Cryo-EM Structural Snapshots of V/A-ATPase Reveal the Rotay Mechanism of Rotary ATPases
نویسندگان
چکیده
回転分子モーターである好熱菌V/A-ATPaseのATP加水分解反応中の複数の中間体構造をクライオ電顕で捉えた．得られた構造から，3つの触媒部位で起こる反応（ATP結合・ATP加水分解・反応産物の放出）と回転軸の120°回転が協奏するtri-site機構で機能することが明らかになった．
منابع مشابه
Rotary ATPases
Rotary ATPases are molecular rotary motors involved in biological energy conversion. They either synthesize or hydrolyze the universal biological energy carrier adenosine triphosphate. Recent work has elucidated the general architecture and subunit compositions of all three sub-types of rotary ATPases. Composite models of the intact F-, V- and A-type ATPases have been constructed by fitting hig...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2022
ISSN: ['0582-4052', '1347-4219']
DOI: https://doi.org/10.2142/biophys.62.354